Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other Inhibitors

Efflux pumps of the resistance nodulation division (RND) superfamily, such as AcrB, make a major contribution to multidrug resistance in Gram-negative bacteria. The development of inhibitors of the RND pumps would improve the efficacy of current and next-generation antibiotics. To date, however, onl...

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Detalhes bibliográficos
Main Authors: Vargiu, Attilio V., Ruggerone, Paolo, Opperman, Timothy J., Nguyen, Son T., Nikaido, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187987/
https://ncbi.nlm.nih.gov/pubmed/25114133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03283-14
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