Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

Alterations in calcium homeostasis are widely reported to contribute to synaptic degeneration and neuronal loss in Alzheimer’s disease. Elevated cytosolic calcium concentrations lead to activation of the calcium-sensitive cysteine protease, calpain, which has a number of substrates known to be abnor...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Kurbatskaya, Ksenia, Phillips, Emma C., Croft, Cara L., Dentoni, Giacomo, Hughes, Martina M., Wade, Matthew A., Al-Sarraj, Safa, Troakes, Claire, O’Neill, Michael J., Perez-Nievas, Beatriz G., Hanger, Diane P., Noble, Wendy
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818436/
https://ncbi.nlm.nih.gov/pubmed/27036949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0299-2
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