Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer’s disease

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by pathological deposits of β-amyloid (Aβ) in senile plaques, intracellular neurofibrillary tangles (NFTs) comprising hyperphosphorylated aggregated tau, synaptic dysfunction and neuronal death. Substantial evidence indicates tha...

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Bibliographic Details
Published in:Aging Cell
Main Authors: Atherton, Joe, Kurbatskaya, Ksenia, Bondulich, Marie, Croft, Cara L, Garwood, Claire J, Chhabra, Resham, Wray, Selina, Jeromin, Andreas, Hanger, Diane P, Noble, Wendy
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326873/
https://ncbi.nlm.nih.gov/pubmed/23919677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12148
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