Molecular Basis of Calpain Cleavage and Inactivation of the Sodium-Calcium Exchanger 1 in Heart Failure

Cardiac sodium (Na(+))-calcium (Ca(2+)) exchanger 1 (NCX1) is central to the maintenance of normal Ca(2+) homeostasis and contraction. Studies indicate that the Ca(2+)-activated protease calpain cleaves NCX1. We hypothesized that calpain is an important regulator of NCX1 in response to pressure over...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Wanichawan, Pimthanya, Hafver, Tandekile Lubelwana, Hodne, Kjetil, Aronsen, Jan Magnus, Lunde, Ida Gjervold, Dalhus, Bjørn, Lunde, Marianne, Kvaløy, Heidi, Louch, William Edward, Tønnessen, Theis, Sjaastad, Ivar, Sejersted, Ole Mathias, Carlson, Cathrine Rein
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256335/
https://ncbi.nlm.nih.gov/pubmed/25336645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.602581
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