Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

Alterations in calcium homeostasis are widely reported to contribute to synaptic degeneration and neuronal loss in Alzheimer’s disease. Elevated cytosolic calcium concentrations lead to activation of the calcium-sensitive cysteine protease, calpain, which has a number of substrates known to be abnor...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Kurbatskaya, Ksenia, Phillips, Emma C., Croft, Cara L., Dentoni, Giacomo, Hughes, Martina M., Wade, Matthew A., Al-Sarraj, Safa, Troakes, Claire, O’Neill, Michael J., Perez-Nievas, Beatriz G., Hanger, Diane P., Noble, Wendy
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818436/
https://ncbi.nlm.nih.gov/pubmed/27036949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0299-2
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