Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

Alterations in calcium homeostasis are widely reported to contribute to synaptic degeneration and neuronal loss in Alzheimer’s disease. Elevated cytosolic calcium concentrations lead to activation of the calcium-sensitive cysteine protease, calpain, which has a number of substrates known to be abnor...

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Bibliografische gegevens
Gepubliceerd in:Acta Neuropathol Commun
Hoofdauteurs: Kurbatskaya, Ksenia, Phillips, Emma C., Croft, Cara L., Dentoni, Giacomo, Hughes, Martina M., Wade, Matthew A., Al-Sarraj, Safa, Troakes, Claire, O’Neill, Michael J., Perez-Nievas, Beatriz G., Hanger, Diane P., Noble, Wendy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2016
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818436/
https://ncbi.nlm.nih.gov/pubmed/27036949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0299-2
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