Therapeutic Targeting of Casein Kinase 1δ in Breast Cancer

Identification of specific drivers of human cancer is required to instruct the development of targeted therapeutics. Here we demonstrate that CSNK1D is amplified and/or overexpressed in human breast tumors and that CK1δ is a vulnerability of human breast cancer subtypes overexpressing this kinase. S...

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Publicat a:Sci Transl Med
Autors principals: Rosenberg, Laura H., Lafite, Marie, Quereda, Victor, Grant, Wayne, Chen, Weimin, Bibian, Mathieu, Noguchi, Yoshihiko, Fallahi, Mohammad, Yang, Chunying, Chang, Jenny C., Roush, William R., Cleveland, John L., Duckett, Derek R.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809734/
https://ncbi.nlm.nih.gov/pubmed/26676609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac8773
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