Therapeutic Targeting of Casein Kinase 1δ in Breast Cancer

Identification of specific drivers of human cancer is required to instruct the development of targeted therapeutics. Here we demonstrate that CSNK1D is amplified and/or overexpressed in human breast tumors and that CK1δ is a vulnerability of human breast cancer subtypes overexpressing this kinase. S...

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Publicado en:Sci Transl Med
Autores principales: Rosenberg, Laura H., Lafite, Marie, Quereda, Victor, Grant, Wayne, Chen, Weimin, Bibian, Mathieu, Noguchi, Yoshihiko, Fallahi, Mohammad, Yang, Chunying, Chang, Jenny C., Roush, William R., Cleveland, John L., Duckett, Derek R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809734/
https://ncbi.nlm.nih.gov/pubmed/26676609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac8773
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