Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties

The development of a series of potent and highly selective casein kinase 1δ/ε (CK1δ/ε) inhibitors is described. Starting from a purine scaffold inhibitor (SR-653234) identified by high throughput screening, we developed a series of potent and highly kinase selective inhibitors, including SR-2890 and...

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Autors principals: Bibian, Mathieu, Rahaim, Ronald J., Choi, Jun Yong, Noguchi, Yoshihiko, Schürer, Stephan, Chen, Weimin, Nakanishi, Shima, Licht, Konstantin, Rosenberg, Laura H., Li, Lin, Feng, Yangbo, Cameron, Michael D., Duckett, Derek R., Cleveland, John L., Roush, William R.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783656/
https://ncbi.nlm.nih.gov/pubmed/23787102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.05.075
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