Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties

The development of a series of potent and highly selective casein kinase 1δ/ε (CK1δ/ε) inhibitors is described. Starting from a purine scaffold inhibitor (SR-653234) identified by high throughput screening, we developed a series of potent and highly kinase selective inhibitors, including SR-2890 and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bibian, Mathieu, Rahaim, Ronald J., Choi, Jun Yong, Noguchi, Yoshihiko, Schürer, Stephan, Chen, Weimin, Nakanishi, Shima, Licht, Konstantin, Rosenberg, Laura H., Li, Lin, Feng, Yangbo, Cameron, Michael D., Duckett, Derek R., Cleveland, John L., Roush, William R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783656/
https://ncbi.nlm.nih.gov/pubmed/23787102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.05.075
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