Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties

The development of a series of potent and highly selective casein kinase 1δ/ε (CK1δ/ε) inhibitors is described. Starting from a purine scaffold inhibitor (SR-653234) identified by high throughput screening, we developed a series of potent and highly kinase selective inhibitors, including SR-2890 and...

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Autori principali: Bibian, Mathieu, Rahaim, Ronald J., Choi, Jun Yong, Noguchi, Yoshihiko, Schürer, Stephan, Chen, Weimin, Nakanishi, Shima, Licht, Konstantin, Rosenberg, Laura H., Li, Lin, Feng, Yangbo, Cameron, Michael D., Duckett, Derek R., Cleveland, John L., Roush, William R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783656/
https://ncbi.nlm.nih.gov/pubmed/23787102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.05.075
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