Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer

Casein kinase 1δ/ε have been identified as promising therapeutic target for oncology application, including breast and brain cancer. Here, we described our continued efforts in optimization of a lead series of purine scaffold inhibitors that led to identification of two new CK1δ/ε inhibitors 17 and...

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Bibliographic Details
Published in:Bioorg Med Chem
Main Authors: Monastyrskyi, Andrii, Nilchan, Napon, Quereda, Victor, Noguchi, Yoshihiko, Ruiz, Claudia, Grant, Wayne, Cameron, Michael, Duckett, Derek, Roush, William
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803353/
https://ncbi.nlm.nih.gov/pubmed/29289448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.12.020
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