Casein Kinase 1δ-dependent Wee1 Protein Degradation

Eukaryotic mitotic entry is controlled by Cdk1, which is activated by the Cdc25 phosphatase and inhibited by Wee1 tyrosine kinase, a target of the ubiquitin proteasome pathway. Here we use a reporter of Wee1 degradation, K328M-Wee1-luciferase, to screen a kinase-directed chemical library. Hit profil...

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Hlavní autoři: Penas, Clara, Ramachandran, Vimal, Simanski, Scott, Lee, Choogon, Madoux, Franck, Rahaim, Ronald J., Chauhan, Ruchi, Barnaby, Omar, Schurer, Stephan, Hodder, Peter, Steen, Judith, Roush, William R., Ayad, Nagi G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081930/
https://ncbi.nlm.nih.gov/pubmed/24817118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.547661
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