GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation

Ubiquitin mediated proteolysis is required for transition from one cell cycle phase to another. For instance, the mitosis inhibitor Wee1 is targeted for degradation during S phase and G2 to allow mitotic entry. Wee1 is an essential tyrosine kinase required for the G2/M transition and S-phase progres...

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Published in:Cell Cycle
Main Authors: Penas, Clara, Mishra, Jitendra K, Wood, Spencer D, Schürer, Stephan C, Roush, William R, Ayad, Nagi G
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353296/
https://ncbi.nlm.nih.gov/pubmed/25616418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.974439
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