WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation

During normal cerebellar development, the remarkable expansion of granule cell progenitors (GCPs) generates a population of granule neurons that outnumbers the total neuronal population of the cerebral cortex, and provides a model for identifying signaling pathways that may be defective in medullobl...

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Detalhes bibliográficos
Main Authors: Anne, Sandrine L., Govek, Eve-Ellen, Ayrault, Olivier, Kim, Jee Hae, Zhu, Xiaodong, Murphy, David A., Van Aelst, Linda, Roussel, Martine F., Hatten, Mary E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841149/
https://ncbi.nlm.nih.gov/pubmed/24303070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081769
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