YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog - dependent cerebellar granule neuron progenitor cells and medulloblastoma cells

Post-natal proliferation of cerebellar granule neuron precursors (CGNPs), proposed cells-of-origin for the SHH-associated subgroup of medulloblastoma (MB), is driven by Sonic Hedgehog (Shh) and Insulin-like Growth Factor (IGF) in the developing cerebellum. Shh induces the oncogene Yes-associated pro...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Dey, Abhinav, Robitaille, Mélanie, Remke, Marc, Maier, Caroline, Malhotra, Anshu, Gregorieff, Alex, Wrana, Jeffrey L, Taylor, Michael D, Angers, Stéphane, Kenney, Anna Marie
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931992/
https://ncbi.nlm.nih.gov/pubmed/26725322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.491
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