MEDU-11. SONIC HEDGEHOG AND REACTIVE OXYGEN SPECIES INTERACT TO REGULATE MITOCHONDRIAL MORPHOLOGY IN MEDULLOBLASTOMA

Sonic hedgehog (Shh) signaling is closely coupled with the bioenergetics of medulloblastoma, the most common malignant pediatric solid tumor. We have reported earlier that Shh causes deregulation of mitochondrial biogenesis by suppressing mitofusins, leading to fragmented mitochondria in vitro as we...

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Publicado en:Neuro Oncol
Main Authors: Malhotra, Anshu, Potts, Chad, Dey, Abhinav, Kenney, Anna M.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475135/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.162
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