WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma

High-level amplification of the protein phosphatase PPM1D (WIP1) is present in a subset of medulloblastomas (MBs) that have an expression profile consistent with active Sonic Hedgehog (SHH) signaling. We found that WIP1 overexpression increased expression of Shh target genes and cell proliferation i...

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Udgivet i:Oncogene
Main Authors: Wen, Jing, Lee, Juhyun, Malhotra, Anshu, Nahta, Rita, Arnold, Amanda R., Buss, Meghan C., Brown, Briana D., Maier, Caroline, Kenney, Anna M., Remke, Marc, Ramaswamy, Vijay, Taylor, Michael D., Castellino, Robert C.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069081/
https://ncbi.nlm.nih.gov/pubmed/27086929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.96
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