Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation

Dicer, a ribonuclease III enzyme, is required for the maturation of microRNAs. To assess its role in cerebellar and medulloblastoma development, we genetically deleted Dicer in Nestin-positive neural progenitors and in mice lacking one copy for the Sonic Hedgehog receptor, Patched 1. We found that c...

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Pubblicato in:PLoS One
Autori principali: Zindy, Frederique, Lee, Youngsoo, Kawauchi, Daisuke, Ayrault, Olivier, Merzoug, Leila Ben, Li, Yang, McKinnon, Peter J., Roussel, Martine F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474721/
https://ncbi.nlm.nih.gov/pubmed/26091048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129642
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