GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation

Ubiquitin mediated proteolysis is required for transition from one cell cycle phase to another. For instance, the mitosis inhibitor Wee1 is targeted for degradation during S phase and G2 to allow mitotic entry. Wee1 is an essential tyrosine kinase required for the G2/M transition and S-phase progres...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Cycle
Prif Awduron: Penas, Clara, Mishra, Jitendra K, Wood, Spencer D, Schürer, Stephan C, Roush, William R, Ayad, Nagi G
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2015
Pynciau:
Reports
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353296/
https://ncbi.nlm.nih.gov/pubmed/25616418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.974439
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