Targeting casein kinase 1 delta sensitizes pancreatic and bladder cancer cells to gemcitabine treatment by upregulating deoxycytidine kinase

Although gemcitabine is the cornerstone of care for pancreatic ductal adenocarcinoma (PDA), patients lack durable responses and relapse is inevitable. While the underlying mechanisms leading to gemcitabine resistance are likely to be multifactorial, there is a strong association between activating g...

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Bibliographic Details
Published in:Mol Cancer Ther
Main Authors: Vena, Francesca, Bayle, Simon, Nieto, Ainhoa, Quereda, Victor, Aceti, Massimiliano, Frydman, Sylvia M., Sansil, Samer S., Grant, Wayne, Monastyrskyi, Andrii, McDonald, Patricia, Roush, William R., Teng, Mingxiang, Duckett, Derek
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415672/
https://ncbi.nlm.nih.gov/pubmed/32430484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0997
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