Targeting casein kinase 1 delta sensitizes pancreatic and bladder cancer cells to gemcitabine treatment by upregulating deoxycytidine kinase

Although gemcitabine is the cornerstone of care for pancreatic ductal adenocarcinoma (PDA), patients lack durable responses and relapse is inevitable. While the underlying mechanisms leading to gemcitabine resistance are likely to be multifactorial, there is a strong association between activating g...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cancer Ther
Prif Awduron: Vena, Francesca, Bayle, Simon, Nieto, Ainhoa, Quereda, Victor, Aceti, Massimiliano, Frydman, Sylvia M., Sansil, Samer S., Grant, Wayne, Monastyrskyi, Andrii, McDonald, Patricia, Roush, William R., Teng, Mingxiang, Duckett, Derek
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415672/
https://ncbi.nlm.nih.gov/pubmed/32430484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0997
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