Gemcitabine Pharmacogenomics: Deoxycytidine Kinase (DCK) and Cytidylate Kinase (CMPK) Gene Resequencing and Functional Genomics

Gemcitabine and other cytidine antimetabolites require metabolic activation by phosphorylation. Deoxycytidine kinase (DCK) and cytidine monophosphate kinase (CMPK) catalyze these reactions. We have applied a genotype-to-phenotype strategy to study DCK and CMPK pharmacogenomics. Specifically, we rese...

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Detalhes bibliográficos
Main Authors: Kocabas, Neslihan Aygun, Aksoy, Pinar, Pelleymounter, Linda L., Moon, Irene, Ryu, Jeong-Seon, Gilbert, Judith A., Salavaggione, Oreste Ezequel, Eckloff, Bruce W., Wieben, Eric D., Yee, Vivien, Weinshilboum, Richard M., Ames, Matthew M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066084/
https://ncbi.nlm.nih.gov/pubmed/18556440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.020925
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