Gemcitabine Pharmacogenomics: Deoxycytidine Kinase (DCK) and Cytidylate Kinase (CMPK) Gene Resequencing and Functional Genomics

Gemcitabine and other cytidine antimetabolites require metabolic activation by phosphorylation. Deoxycytidine kinase (DCK) and cytidine monophosphate kinase (CMPK) catalyze these reactions. We have applied a genotype-to-phenotype strategy to study DCK and CMPK pharmacogenomics. Specifically, we rese...

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Bibliographic Details
Main Authors:	Kocabas, Neslihan Aygun, Aksoy, Pinar, Pelleymounter, Linda L., Moon, Irene, Ryu, Jeong-Seon, Gilbert, Judith A., Salavaggione, Oreste Ezequel, Eckloff, Bruce W., Wieben, Eric D., Yee, Vivien, Weinshilboum, Richard M., Ames, Matthew M.
Format:	Artigo
Language:	Inglês
Published:	2008
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3066084/ https://ncbi.nlm.nih.gov/pubmed/18556440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.020925
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Gemcitabine Pharmacogenomics: Deoxycytidine Kinase (DCK) and Cytidylate Kinase (CMPK) Gene Resequencing and Functional Genomics

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