Gemcitabine Pharmacogenomics: Deoxycytidine Kinase (DCK) and Cytidylate Kinase (CMPK) Gene Resequencing and Functional Genomics

Gemcitabine and other cytidine antimetabolites require metabolic activation by phosphorylation. Deoxycytidine kinase (DCK) and cytidine monophosphate kinase (CMPK) catalyze these reactions. We have applied a genotype-to-phenotype strategy to study DCK and CMPK pharmacogenomics. Specifically, we rese...

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Bibliografski detalji
Glavni autori: Kocabas, Neslihan Aygun, Aksoy, Pinar, Pelleymounter, Linda L., Moon, Irene, Ryu, Jeong-Seon, Gilbert, Judith A., Salavaggione, Oreste Ezequel, Eckloff, Bruce W., Wieben, Eric D., Yee, Vivien, Weinshilboum, Richard M., Ames, Matthew M.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066084/
https://ncbi.nlm.nih.gov/pubmed/18556440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.020925
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