P2Y(12) receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation

AIMS: In vivo platelet function is a product of intrinsic platelet reactivity, modifiable by dual antiplatelet therapy (DAPT), and the extrinsic inhibitory endothelial mediators, nitric oxide (NO) and prostacyclin (PGI(2)), that are powerfully potentiated by P2Y(12) receptor blockade. This implies t...

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Bibliografske podrobnosti
izdano v:Br J Clin Pharmacol
Main Authors: Chan, Melissa V., Knowles, Rebecca B. M., Lundberg, Martina H., Tucker, Arthur T., Mohamed, Nura A., Kirkby, Nicholas S., Armstrong, Paul C. J., Mitchell, Jane A., Warner, Timothy D.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Translational Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799935/
https://ncbi.nlm.nih.gov/pubmed/26561399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12826
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