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The kinase activity of PKR represses inflammasome activity
The protein kinase R (PKR) functions in the antiviral response by controlling protein translation and inflammatory cell signaling pathways. We generated a transgenic, knock-in mouse in which the endogenous PKR is expressed with a point mutation that ablates its kinase activity. This novel animal all...
Kaydedildi:
| Yayımlandı: | Cell Res |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4783464/ https://ncbi.nlm.nih.gov/pubmed/26794869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.11 |
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