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A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR
A key step in the activation of interferon-inducible antiviral kinase PKR involves differential binding of viral double-stranded RNA (dsRNA) to its two structurally similar N-terminal dsRNA binding motifs, dsRBM1 and dsRBM2. We show here, using NMR spectroscopy, that dsRBM1 with higher RNA binding a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC314023/ https://ncbi.nlm.nih.gov/pubmed/11032824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.20.5567 |
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