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A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR
A key step in the activation of interferon-inducible antiviral kinase PKR involves differential binding of viral double-stranded RNA (dsRNA) to its two structurally similar N-terminal dsRNA binding motifs, dsRBM1 and dsRBM2. We show here, using NMR spectroscopy, that dsRBM1 with higher RNA binding a...
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| 出版年: | EMBO J |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2000
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314023/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11032824/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.20.5567 |
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