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Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation.

Protein kinase PKR is an interferon-induced enzyme that plays a key role in the control of viral infections and cellular homeostasis. Compared with other known kinases, PKR is activated by a distinct mechanism that involves double-stranded RNA (dsRNA) binding in its N-terminal region in an RNA seque...

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Bibliografski detalji
Glavni autori: Nanduri, S, Carpick, B W, Yang, Y, Williams, B R, Qin, J
Format: Artigo
Jezik:Inglês
Izdano: 1998
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170871/
https://ncbi.nlm.nih.gov/pubmed/9736623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.18.5458
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