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The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation
Melanoma differentiation‐associated protein 5 (MDA5) mediates the innate immune response to viral infection. Polymorphisms in IFIH1, the gene coding for MDA5, correlate with the risk of developing type 1 diabetes (T1D). Here, we demonstrate that MDA5 is crucial for the immune response to enteric rot...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5599799/ https://ncbi.nlm.nih.gov/pubmed/28851763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696273 |
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