Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71

Heat shock protein 90 (Hsp90) is an ATP dependent molecular chaperone protein whose function is critical for maintaining several key proteins involved in survival and proliferation of cancer cells. PU-H71 (1) is a potent purine-scaffold based ATP pocket binding Hsp90 inhibitor which has been shown t...

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Veröffentlicht in:J Labelled Comp Radiopharm
Hauptverfasser: Taldone, Tony, Zatorska, Danuta, Ochiana, Stefan O., Smith-Jones, Peter, Koziorowski, Jacek, Dunphy, Mark P., Zanzonico, Pat, Bolaender, Alexander, Lewis, Jason S., Larson, Steven M., Chiosis, Gabriela, Pillarsetty, Nagavarakishore
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779400/
https://ncbi.nlm.nih.gov/pubmed/26806023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3369
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