Measuring Tumor Epichaperome Expression Using [(124)I] PU-H71 Positron Emission Tomography as a Biomarker of Response for PU-H71 Plus Nab-Paclitaxel in HER2-Negative Metastatic Breast Cancer

PURPOSE: Epichaperome network maintenance is vital to survival of tumors that express it. PU-H71 is an epichaperome inhibitor that binds to the ATP-binding site of HSP90 and has demonstrated antitumor activity in breast cancer xenograft models and clinical safety in patients. PU–positron emission to...

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Bibliografiska uppgifter
I publikationen:JCO Precis Oncol
Huvudupphovsmän: Jhaveri, Komal L., dos Anjos, Carlos H., Taldone, Tony, Wang, Rui, Comen, Elizabeth, Fornier, Monica, Bromberg, Jacqueline F., Ma, Weining, Patil, Sujata, Rodina, Anna, Pillarsetty, Nagavarakishore, Duggan, Susan, Khoshi, Sarhe, Kadija, Nathan, Chiosis, Gabriela, Dunphy, Mark P., Modi, Shanu
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Clinical Oncology 2020
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ORIGINAL REPORTS
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7713524/
https://ncbi.nlm.nih.gov/pubmed/33283132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00273
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