First-in-Human Trial of Epichaperome-Targeted Positron Emission Tomography in Cancer Patients

PURPOSE: (124)I-PU-H71 is an investigational first-in-class radiologic agent specific for imaging tumor epichaperome formations. The intracellular epichaperome forms under cellular stress and is a clinically validated oncotherapeutic target. We conducted a first-in-human study of microdose (124)I-PU...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Dunphy, Mark P., Pressl, Christina, Pillarsetty, Nagavarakishore, Grkovski, Milan, Modi, Shanu, Jhaveri, Komal, Norton, Larry, Beattie, Bradley J., Zanzonico, Pat B., Zatorska, Danuta, Taldone, Tony, Ochiana, Stefan O., Uddin, Mohammad M., Burnazi, Eva M., Lyashchenko, Serge K., Hudis, Clifford A., Bromberg, Jacqueline F., Schöder, Heiko M., Fox, Josef J., Zhang, Hanwen, Chiosis, Gabriela, Lewis, Jason S., Larson, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541604/
https://ncbi.nlm.nih.gov/pubmed/32366671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-3704
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