Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71

Heat shock protein 90 (Hsp90) is an ATP dependent molecular chaperone protein whose function is critical for maintaining several key proteins involved in survival and proliferation of cancer cells. PU-H71 (1) is a potent purine-scaffold based ATP pocket binding Hsp90 inhibitor which has been shown t...

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Библиографические подробности
Опубликовано в: :J Labelled Comp Radiopharm
Главные авторы: Taldone, Tony, Zatorska, Danuta, Ochiana, Stefan O., Smith-Jones, Peter, Koziorowski, Jacek, Dunphy, Mark P., Zanzonico, Pat, Bolaender, Alexander, Lewis, Jason S., Larson, Steven M., Chiosis, Gabriela, Pillarsetty, Nagavarakishore
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779400/
https://ncbi.nlm.nih.gov/pubmed/26806023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3369
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