Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71

Heat shock protein 90 (Hsp90) is an ATP dependent molecular chaperone protein whose function is critical for maintaining several key proteins involved in survival and proliferation of cancer cells. PU-H71 (1) is a potent purine-scaffold based ATP pocket binding Hsp90 inhibitor which has been shown t...

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Bibliografske podrobnosti
izdano v:J Labelled Comp Radiopharm
Main Authors: Taldone, Tony, Zatorska, Danuta, Ochiana, Stefan O., Smith-Jones, Peter, Koziorowski, Jacek, Dunphy, Mark P., Zanzonico, Pat, Bolaender, Alexander, Lewis, Jason S., Larson, Steven M., Chiosis, Gabriela, Pillarsetty, Nagavarakishore
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779400/
https://ncbi.nlm.nih.gov/pubmed/26806023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3369
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