A higher-order entity formed by the flexible assembly of RAP1 with TRF2

Telomere integrity is essential to maintain genome stability, and telomeric dysfunctions are associated with cancer and aging pathologies. In human, the shelterin complex binds TTAGGG DNA repeats and provides capping to chromosome ends. Within shelterin, RAP1 is recruited through its interaction wit...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Gaullier, Guillaume, Miron, Simona, Pisano, Sabrina, Buisson, Rémi, Le Bihan, Yann-Vaï, Tellier-Lebègue, Carine, Messaoud, Wala, Roblin, Pierre, Guimarães, Beatriz G., Thai, Robert, Giraud-Panis, Marie-Josèphe, Gilson, Eric, Le Du, Marie-Hélène
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
Structural Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770236/
https://ncbi.nlm.nih.gov/pubmed/26748096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1531
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