The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres

The stability of mammalian telomeres depends upon TRF2, which prevents inappropriate repair and checkpoint activation. By using a plasmid integration assay in yeasts carrying humanized telomeres, we demonstrated that TRF2 possesses the intrinsic property to both stimulate initial homologous recombin...

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Detalhes bibliográficos
Main Authors: Saint-Léger, Adélaïde, Koelblen, Melanie, Civitelli, Livia, Bah, Amadou, Djerbi, Nadir, Giraud-Panis, Marie-Josèphe, Londoño-Vallejo, Arturo, Ascenzioni, Fiorentina, Gilson, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128890/
https://ncbi.nlm.nih.gov/pubmed/25483196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29422
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