TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

The shelterin protein protects telomeres against activation of the DNA damage checkpoint and recombinational repair. We show here that a dimer of the shelterin subunit TRF2 wraps ~90 bp of DNA through several lysine and arginine residues localized around its homodimerization domain. The expression o...

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Bibliografiska uppgifter
I publikationen:Mol Cell
Huvudupphovsmän: Benarroch-Popivker, Delphine, Pisano, Sabrina, Mendez-Bermudez, Aaron, Lototska, Liudmyla, Kaur, Parminder, Bauwens, Serge, Djerbi, Nadir, Latrick, Chrysa M., Fraisier, Vincent, Pei, Bei, Gay, Alexandre, Jaune, Emilie, Foucher, Kevin, Cherfils-Vicini, Julien, Aeby, Eric, Miron, Simona, Londoño-Vallejo, Arturo, Ye, Jing, Le Du, Marie-Hélène, Wang, Hong, Gilson, Eric, Giraud-Panis, Marie-Josèphe
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001171/
https://ncbi.nlm.nih.gov/pubmed/26774283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.12.009
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