TRF2/RAP1 and DNA–PK mediate a double protection against joining at telomeric ends

DNA-dependent protein kinase (DNA-PK) is a double-strand breaks repair complex, the subunits of which (KU and DNA-PKcs) are paradoxically present at mammalian telomeres. Telomere fusion has been reported in cells lacking these proteins, raising two questions: how is DNA–PK prevented from initiating...

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Main Authors: Bombarde, Oriane, Boby, Céline, Gomez, Dennis, Frit, Philippe, Giraud-Panis, Marie-Josèphe, Gilson, Eric, Salles, Bernard, Calsou, Patrick
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876953/
https://ncbi.nlm.nih.gov/pubmed/20407424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.49
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