Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

Macrophage activation/polarization to distinct functional states is critically supported by metabolic shifts. How polarizing signals coordinate metabolic and functional reprogramming, and the potential implications for control of macrophage activation, remains poorly understood. Here we show that IL...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Covarrubias, Anthony J, Aksoylar, Halil Ibrahim, Yu, Jiujiu, Snyder, Nathaniel W, Worth, Andrew J, Iyer, Shankar S, Wang, Jiawei, Ben-Sahra, Issam, Byles, Vanessa, Polynne-Stapornkul, Tiffany, Espinosa, Erika C, Lamming, Dudley, Manning, Brendan D, Zhang, Yijing, Blair, Ian A, Horng, Tiffany
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769166/
https://ncbi.nlm.nih.gov/pubmed/26894960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11612
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