The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1

BACKGROUND: Nuclear factor E2 related factor-2 (Nrf2) is an oxidative stress inducible transcription factor being essential in regulating cell homeostasis. Thus, acute induction of Nrf2 in epithelial cells exposed to inflammation confers protection from oxidative cell damage and mutagenesis supporti...

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Bibliografski detalji
Izdano u:BMC Cancer
Glavni autori: Genrich, Geeske, Kruppa, Marcus, Lenk, Lennart, Helm, Ole, Broich, Anna, Freitag-Wolf, Sandra, Röcken, Christoph, Sipos, Bence, Schäfer, Heiner, Sebens, Susanne
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766703/
https://ncbi.nlm.nih.gov/pubmed/26915435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2191-7
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