The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1

BACKGROUND: Nuclear factor E2 related factor-2 (Nrf2) is an oxidative stress inducible transcription factor being essential in regulating cell homeostasis. Thus, acute induction of Nrf2 in epithelial cells exposed to inflammation confers protection from oxidative cell damage and mutagenesis supporti...

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Détails bibliographiques
Publié dans:BMC Cancer
Auteurs principaux: Genrich, Geeske, Kruppa, Marcus, Lenk, Lennart, Helm, Ole, Broich, Anna, Freitag-Wolf, Sandra, Röcken, Christoph, Sipos, Bence, Schäfer, Heiner, Sebens, Susanne
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766703/
https://ncbi.nlm.nih.gov/pubmed/26915435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2191-7
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