CD4(+) T cells potently induce epithelial-mesenchymal-transition in premalignant and malignant pancreatic ductal epithelial cells–novel implications of CD4(+) T cells in pancreatic cancer development

Chronic pancreatitis (CP) is a risk factor of pancreatic ductal adenocarcinoma (PDAC) and characterized by a pronounced desmoplastic reaction with CD4(+) T cells accounting for the majority of the stromal T cell infiltrate. Epithelial-mesenchymal-transition (EMT) is a critical process for metastasis...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Goebel, Lisa, Grage-Griebenow, Evelin, Gorys, Artur, Helm, Ole, Genrich, Geeske, Lenk, Lennart, Wesch, Daniela, Ungefroren, Hendrik, Freitag-Wolf, Sandra, Sipos, Bence, Röcken, Christoph, Schäfer, Heiner, Sebens, Susanne
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485733/
https://ncbi.nlm.nih.gov/pubmed/26137395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2014.1000083
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