Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling

Transforming growth factor (TGF)-β1 promotes progression of pancreatic ductal adenocarcinoma (PDAC) by enhancing epithelial-mesenchymal transition, cell migration/invasion, and metastasis, in part by cooperating with the small GTPase Rac1. Prompted by the observation of higher expression of Rac1b, a...

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Autores principales: Ungefroren, Hendrik, Sebens, Susanne, Giehl, Klaudia, Helm, Ole, Groth, Stephanie, Fändrich, Fred, Röcken, Christoph, Sipos, Bence, Lehnert, Hendrik, Gieseler, Frank
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2013
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960208/
https://ncbi.nlm.nih.gov/pubmed/24378395
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