Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel

GLIC receptor is a bacterial pentameric ligand-gated ion channel whose action is inhibited by xenon. Xenon has been used in clinical practice as a potent gaseous anaesthetic for decades, but the molecular mechanism of interactions with its integral membrane receptor targets remains poorly understood...

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Bibliographic Details
Published in:PLoS One
Main Authors: Sauguet, Ludovic, Fourati, Zeineb, Prangé, Thierry, Delarue, Marc, Colloc'h, Nathalie
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765991/
https://ncbi.nlm.nih.gov/pubmed/26910105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149795
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