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Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels
To understand the molecular mechanism of ion permeation in pentameric ligand-gated ion channels (pLGIC), we solved the structure of an open form of GLIC, a prokaryotic pLGIC, at 2.4 Å. Anomalous diffraction data were used to place bound anions and cations. This reveals ordered water molecules at the...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
European Molecular Biology Organization
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3590989/ https://ncbi.nlm.nih.gov/pubmed/23403925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.17 |
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