Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

To understand the molecular mechanism of ion permeation in pentameric ligand-gated ion channels (pLGIC), we solved the structure of an open form of GLIC, a prokaryotic pLGIC, at 2.4 Å. Anomalous diffraction data were used to place bound anions and cations. This reveals ordered water molecules at the...

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Auteurs principaux: Sauguet, Ludovic, Poitevin, Frédéric, Murail, Samuel, Van Renterghem, Catherine, Moraga-Cid, Gustavo, Malherbe, Laurie, Thompson, Andrew W, Koehl, Patrice, Corringer, Pierre-Jean, Baaden, Marc, Delarue, Marc
Format: Artigo
Langue:Inglês
Publié: European Molecular Biology Organization 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590989/
https://ncbi.nlm.nih.gov/pubmed/23403925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.17
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