Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel

The pentameric ligand-gated ion channel (pLGIC) from Gloeobacter violaceus (GLIC) has provided insightful structure–function views on the permeation process and the allosteric regulation of the pLGICs family. However, GLIC is activated by pH instead of a neurotransmitter and a clear picture for the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hu, Haidai, Ataka, Kenichi, Menny, Anaïs, Fourati, Zaineb, Sauguet, Ludovic, Corringer, Pierre-Jean, Koehl, Patrice, Heberle, Joachim, Delarue, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310827/
https://ncbi.nlm.nih.gov/pubmed/30541892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813378116
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