Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation

Lignende værker

• Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel
  af: Hu, Haidai, et al.
  Udgivet: (2018)
• Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel
  af: Nemecz, Ákos, et al.
  Udgivet: (2017)
• Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel
  af: Fourati, Zaineb, et al.
  Udgivet: (2020)
• Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation
  af: Sauguet, Ludovic, et al.
  Udgivet: (2014)
• Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel
  af: Sauguet, Ludovic, et al.
  Udgivet: (2016)