Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation

Pentameric ligand-gated ion channels (pLGICs) constitute a widespread class of ion channels, present in archaea, bacteria, and eukaryotes. Upon binding of their agonists in the extracellular domain, the transmembrane pore opens, allowing ions to go through, via a gating mechanism that can be modulat...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Hu, Haidai, Nemecz, Ákos, Van Renterghem, Catherine, Fourati, Zaineb, Sauguet, Ludovic, Corringer, Pierre-Jean, Delarue, Marc
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2018
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924894/
https://ncbi.nlm.nih.gov/pubmed/29632192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717700115
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