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Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel

GLIC receptor is a bacterial pentameric ligand-gated ion channel whose action is inhibited by xenon. Xenon has been used in clinical practice as a potent gaseous anaesthetic for decades, but the molecular mechanism of interactions with its integral membrane receptor targets remains poorly understood...

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發表在:PLoS One
Main Authors: Sauguet, Ludovic, Fourati, Zeineb, Prangé, Thierry, Delarue, Marc, Colloc'h, Nathalie
格式: Artigo
語言:Inglês
出版: Public Library of Science 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765991/
https://ncbi.nlm.nih.gov/pubmed/26910105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149795
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