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Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation
Pentameric ligand-gated ion channels mediate fast chemical transmission of nerve signals. The structure of a bacterial proton-gated homolog has been established in its open and locally closed conformations at acidic pH. Here we report its crystal structure at neutral pH, thereby providing the X-ray...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3903189/ https://ncbi.nlm.nih.gov/pubmed/24367074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314997111 |
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