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The dual‐gate model for pentameric ligand‐gated ion channels activation and desensitization

Pentameric ligand‐gated ion channels (pLGICs) mediate fast neurotransmission in the nervous system. Their dysfunction is associated with psychiatric, neurological and neurodegenerative disorders such as schizophrenia, epilepsy and Alzheimer's disease. Understanding their biophysical and pharmac...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Gielen, Marc, Corringer, Pierre‐Jean
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5978336/
https://ncbi.nlm.nih.gov/pubmed/29484660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275100
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