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The dual‐gate model for pentameric ligand‐gated ion channels activation and desensitization

Pentameric ligand‐gated ion channels (pLGICs) mediate fast neurotransmission in the nervous system. Their dysfunction is associated with psychiatric, neurological and neurodegenerative disorders such as schizophrenia, epilepsy and Alzheimer's disease. Understanding their biophysical and pharmac...

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Detalles Bibliográficos
Publicado en:J Physiol
Main Authors: Gielen, Marc, Corringer, Pierre‐Jean
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5978336/
https://ncbi.nlm.nih.gov/pubmed/29484660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275100
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