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Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

Ethanol alters nerve signalling by interacting with proteins in the central nervous system, particularly pentameric ligand-gated ion channels. A recent series of mutagenesis experiments on Gloeobacter violaceus ligand-gated ion channel, a prokaryotic member of this family, identified a single-site v...

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Bibliografiska uppgifter
Huvudupphovsmän: Sauguet, Ludovic, Howard, Rebecca J., Malherbe, Laurie, Lee, Ui S., Corringer, Pierre-Jean, Harris, R. Adron, Delarue, Marc
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4204805/
https://ncbi.nlm.nih.gov/pubmed/23591864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2682
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