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Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

Despite its long history of use and abuse in human culture, the molecular basis for alcohol action in the brain is poorly understood. The recent determination of the atomic-scale structure of GLIC, a prokaryotic member of the pentameric ligand-gated ion channel (pLGIC) family, provides a unique oppo...

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Autores principales: Howard, Rebecca J., Murail, Samuel, Ondricek, Kathryn E., Corringer, Pierre-Jean, Lindahl, Erik, Trudell, James R., Harris, R. Adron
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141919/
https://ncbi.nlm.nih.gov/pubmed/21730162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104480108
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