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Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

Despite its long history of use and abuse in human culture, the molecular basis for alcohol action in the brain is poorly understood. The recent determination of the atomic-scale structure of GLIC, a prokaryotic member of the pentameric ligand-gated ion channel (pLGIC) family, provides a unique oppo...

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Hlavní autoři: Howard, Rebecca J., Murail, Samuel, Ondricek, Kathryn E., Corringer, Pierre-Jean, Lindahl, Erik, Trudell, James R., Harris, R. Adron
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141919/
https://ncbi.nlm.nih.gov/pubmed/21730162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104480108
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